Members of the Centre for Research in Biosciences (CRIB)
Director
| Name | Key research interests |
|---|---|
|
Professor Aniko Varadi |
Biomedical genetics, Type 2 diabetes. |
Staff members
| Name | Key research interests |
|---|---|
|
Senior Lecturer (Biomedical Science) and Employability Lead - Coordinator UWE Bristol Africa Network and Africa Week |
Community acquired infections, hospital acquired infections, biofilms, antimicrobial agents, essential oils, disinfection. |
|
Senior Lecturer in Molecular Genetics |
Ecological risk assessment of GM crops, crop improvement, environmental monitoring and DNA barcoding. |
|
Senior Lecturer, Haematology |
Acute Myeloid Leukaemia, bacterial bioluminescence biosensors, cell biology. |
|
Research Fellow |
Control of disease through the development of novel biosensor technologies for use in rapid point-of-care diagnostics. Particular areas of interest include development of magnetic detection technologies using paramagnetic particles and development of diagnostics for infectious diseases, cancer and Alzheimer's with novel biomarkers. |
|
Senior Lecturer in Environmental Science |
Biogeochemistry, extracellular enzyme activities, greenhouse gas production, biochar, wetlands. |
| Dr Carrie Brady |
Microbial taxonomy. |
|
Technician |
Molecular biotechnology, recombinant gene expression and transformation systems, reporter gene development. |
|
Professor of Biomedical Science |
Clinical biochemistry, metabolic biochemistry, the role of the branched chain aminotransferase (BCAT) proteins in glutamate toxicity, a key contributor to the pathogenesis of neurodegenerative disorders such as Alzheimer's Disease. |
|
Laboratory Manager - Biomedical Research |
Laboratory manager. |
|
Senior Lecturer - Environmental Microbiology |
Bio-sensors, environmental monitoring, food analysis. |
|
Senior Research Lecturer, Physiology |
The role of protein SUMOylation in glucose homeostasis and type-II diabetes. |
|
Senior Lecturer |
Mucosal immunology. |
|
Senior Research Fellow |
Chemical sensors and targeted sensor arrays for disease diagnosis, biomarker identification using SPME and ATD coupled with GCMS, chemical computing using the Belousov Zhabotinsky reaction, pattern forming reactions. |
|
Senior Lecturer - Healthcare/Biomedical Science |
Breast cancer and cellular pathology. |
| Professor Olena Doran
Associate Dean (Research) and Professor in Biomedical Research |
Molecular mechanisms of food quality in relation to human health, identification of biomarkers and development of genetic tests for pathological states and food quality, lipid metabolism. |
|
Lecturer |
Wildlife populations, conservation threats, policy recommendations; large-scale bio-monitoring programs to remotely monitor wildlife, detect illegal human activity and identify priority areas for conservation; development of environmental education and outreach activities. |
|
Senior Lecturer in Biomedical Sciences |
Cancer biology, tumour microenvironment, signal transduction, hypoxia, autophagy, apoptosis, drug discovery, bioinformatics. |
|
Emeritus Professor John Greenman Professor of Microbiology |
Microbial fuel cells, oral malodour, in vitro biofilms, growth, ecology and physiology of microbes: biofilm and planktonic continuous culture. |
|
Professor in Cell Signalling |
The production and role of reactive oxygen and reactive nitrogen species, as well as hydrogen sulfide, in biological systems with a focus on cell signalling. |
|
Professor in Biosensor and Electroanalytical Sciences |
Disposable screen-printed electrochemical sensors and biosensors for applications in biomedicine, environmental studies and agri-food analysis; HPLC/Electrochemical detection for the determination of trace levels of vitamins, coenzymes and drugs. |
|
Departmental Academic Director |
Stability analyses in sustainable energy production, medicine and biology, blood flow in the microcirculation, solar ponds; nonlinear energy theory. |
|
Senior Lecturer |
Chemistry. |
|
Research Fellow |
Electrochemistry, sensors, chromatography, HPLC, GC, GC-MS. |
|
Lecturer |
Radioacivity, protein biochemistry, physiology. |
|
Professor of Biomedical Sciences |
Development of chemical sensors, biosensors and biomedical diagnostic devices. |
|
Senior Lecturer |
Biological and cognitive markers of development related disorders such as dementia (Alzheimer's disease), autism and dyslexia. |
|
Associate Professor Biomedical Science |
Alternative splicing in cancer, regulation of alternative splicing through the SR protein kinase SRPK1, the oncogenic splice factor SFRS1, alternative splicing of VEGF, HER2, H-Ras, Insulin Receptor and ERG, role of the TMPRSS2/ERG microdeletion in prostate cancer, the tumour suppressor gene WT1 in development and disease, the stress-associated RNA-binding protein at GRP7/RBM3, identification of plant-derived compounds with splicing modulatory activity. |
|
Senior Lecturer in Medical Microbiology and Programme Leader for MSc in Biomedical Science |
Moraxella cattarhalis (a pathogen of the mucous membranes such as the respiratory tract, eyes and inner ear), the molecular epidemiology of pathogenic bacteria, biomedical ethics and philosophy. |
|
Molecular Biology/ Immunology Technician |
Microbial fuel cells, microbiology, molecular biology, urinary tract. |
|
Senior Lecturer |
Effects of air pollution on tree health, woodlands and calcareous grasslands, impacts of trees on urban air quality, development of environmental policy within the electricity industry, use of science in environmental policy development, effect of legislation on the implementation of environmental policy, public understanding of Global Climate Change. |
| Dr Paul Lintott Lecturer in Conservation Science |
How modern challenges, such as urban expansion, persecution, noise pollution, and agricultural intensification, impact wildlife, and the close interaction with stakeholders, and the identification of sustainable and practical solutions being an explicit aim. |
|
Director Institute of Bio-Sensing Technology |
Developing new rapid diagnostic technologies for point of care diagnostics and environmental analysis, magnetic immunoassay and whole cell impedance and imaging, working with industry and developing academic/industrial collaboration and networking. |
|
Senior Lecturer in Molecular Biology |
Auxin perception; signal transduction and proteomic responses to biotic and abiotic stresses; microalgal biofuels. |
|
Associate Professor (Hard Tissue Biology)Biomedical Science |
Osteoblasts, differentiation, active vitamin D3, titanium functionalisation, lysophosphatidic acid (LPA) and LPA analogues. |
|
Lecturer in Environmental Chemistry |
Biogeochemistry, organic geochemistry, stable isotopes, mass spectrometry. |
|
Lecturer in Biomedical Science |
Haematology, bone marrow, stem cell transplantation, chemotherapy. |
|
Professor in Bioanalyitical Science |
High performance liquid chromatography (HPLC) and gas chromatography (GC) to the solution of problems especially in biomedical and pharmaceutical science. |
|
Dr Natasha McGuire Research Support Technician |
Sensor development and testing: volatile analysis, metal oxide semiconductors, electrochemical, biosensors, gas chromatography and screen-printing. Applications: detection of carbon dioxide and diagnosis of C.difficile, Norovirus, IBD and IBS. |
|
Senior Lecturer, Anatomy & Physiology |
Anatomy, Physiology, creating e-learning resources for scientific and medical education, dental science. |
|
Senior Lecturer in Biomedical Sciences (Human Genetics) |
The molecular biology of stem cell transplantation, the aetiology of haemopoietic malignancy. |
|
Research Fellow |
Molecular Genetics and Microbiology; molecular plant-microbe interactions. |
|
Senior Lecturer |
Bacterial biofilms, Pseudomonas aeruginosa, bioluminescence as a monitor of bacterial metabolic activity, probiotics. |
|
Head of Department of Applied Sciences |
Detecting stress in marine invertebrates and fish, the use of biomarkers, sub-lethal effects of oil pollution on echinoderms, the predictive capacity of toxicity tests, the effects of long-term exposure to metal contamination on marine invertebrates. |
|
Senior Lecturer |
Biomolecular modelling, molecular dynamics simulation, interfaces, lipids, membranes, water, proteins, permeation |
|
Senior Lecturer |
The pharmacology of the functional and dysfunctional blood-brain barrier in response to disease and toxicological stresses, current projects relating to glutamate excitotoxicity in neurological conditions where there is a neurovascular component, namely Alzheimer's disease and Multiple Sclerosis, also the nanotoxicity of nanoparticles at the blood-brain and placental barriers. |
|
Senior Lecturer |
Developing novel biosensors by combining biological recognition elements (antibodies/enzymes) with electrodes, use of screen-printing technology to fabricate electrodes from carbon-containing inks as the basis for electrochemical sensing devices, applying enzyme biosensors to monitor cell metabolism in culture. |
|
Research Fellow |
Electrochemistry, Sensor, biosensor, material science, enzyme stabilisation, analytical chemistry, elisa assay, magneto immuno sensor. |
|
Senior Lecturer |
Tumour invasion and metastasis, wound healing in inflammatory disease. |
|
Professor in Materials and Sensors Science |
Volatile analysis, sensor and device fabrication and testing of commercial sensors, aerospace industry, molecular electronics, nuclear industry. |
|
Professor of Health and Environment |
Dissolved organic matter fluorescence and water quality, biological and chemical decontamination in healthcare environments using electrochemically activated solutions, visualisation of biological and chemical processes using low light detection and imaging. |
|
Senior Lecturer - Microbiology |
The applications of bacterial bioluminescence, the transfer of genes from naturally bioluminescent bacteria to bacteria. |
|
Senior Research Fellow |
Oral malodour, in vitro biofilm models, clinical trials to study the anti malodour effects of medicated formulations (malodour counteractives), microbiology of exfoliative surfaces. |
|
Emerita Professor Vyv Salisbury Professor of Applied Microbiology |
Use of bioluminescent clinical strains of significant bacterial pathogens for evaluation of the pharmacodynamic effects of antibiotics, use of bacterial bioluminescence as an intracellular reporter, use of bioluminescent strains of food borne pathogens for evaluation of heat treatment of foods, effect of low dose macrolide antibiotics on bacterial cell signalling. |
|
Senior Lecturer - Environmental Science |
Environmental science. |
|
Lecturer |
Monitoring the impacts of conservation efforts at the landscape level. Potential of Payments for Ecosystem Services as a funding mechanism for lowland wetlands. Impact of species reintroductions on ecological function. |
|
Senior Lecturer - Physiology |
Exercise physiology, exercise and health. |
|
Senior Lecturer in Human Genetics and Genomics |
Genetic toxicology, DNA damage response, 3D image reconstruction, cancer stem cells. |
| Dr Rhian Thomas
Senior Lecturer in Human Physiology |
Alzheimer's disease, antibody-based therapies, underlying mechanisms of disease, neurodegeneration, molecular neurosciences, cell biology and biochemistry. |
|
Senior Lecturer in Biological Sciences |
Applied microbiology. |
|
Programme Leader - Environment |
Environmental research. |
|
Lecturer - Molecular Biology |
Bacteriophage biology and genomics. |
|
Senior Lecturer-Physiology, and International Partnership Co-ordinator |
Physiological and pharmacological function of lower urinary tract in health and disease. Development of isolated animal bladder models for studying the integrative physiology of the bladder. |
|
Lecturer |
Impacts of environmental change on wetland and upland ecosystems, focusing on behavior, physiology and population dynamics; data analysis and statistics, using ecological models to address applied issues in industry, wildlife management and conservation. |
|
Senior Lecturer |
Plant germplasm conservation, plant virology and DNA barcoding. |
|
Senior Lecturer in Haematology |
Immunology, with subheadings of auto-immunity, vaccines and viral immunity, inflammatory diseases, macrophage biology and amyloid disease. |
|
Professor of Environmental Plant Physiology and Director of UWE Bristol Graduate School |
Radionuclides, heavy metals and organics in the soil-plant system. Predicting the uptake and effects of contaminant radionuclides for food contamination studies and environmental assessments. The use of phylogenetic, ionomic and molecular techniques to understand the behaviour of toxic inorganics in plants. |
|
Senior Lecturer |
Cell signalling, ethylene, re-active oxygen species. |
|
Senior Lecturer -Healthcare Science |
Investigating changes in cardiovascular ion channel function induced by disease states and by pharmacological modulation, the relationship between ion channel function and calcium release in cells of the cardiac conduction system, and how ion channel function is altered in diseases like Diabetes. |
PhD students
| Name | Title of PhD |
|---|---|
| Hanan Alabouh | Regulation of alternative splicing in leukaemia by the Splice Factor Kinase SRPK1 |
| Layla Al Hajab | Role of the GRP RNA binding proteins in stress adaptation in Chlamydomonas reinhardtii |
| Sultan Almalki | Optimisation of haematopoietic stem cell homing post-transplantation, using an in vitro model of the bone marrow/vasculature interface |
| Elizabeth Bowler | The effect of hypoxia on alternative splicing in prostate cancer |
| Nicol Caplin | NERC radioactivity and the terrestrial environment (RATE) programme studentship: the biological effects of ionizing radiation |
| Claire Caygill | The role of pancreatic islet cell glutamate receptors in endocrine hormone secretion and in the development of diabetes |
| Gillian Clayton | The development of off-grid water treatment technologies for the recovery of agricultural wastes |
| Mike Devey | Investigating biomarkers of triple negative breast cancer |
| Julian Donald | What is the relationship between biodiversity and ecosystem function? |
| Arwa Flemban | Investigation of new tissue biomarkers for triple negative breast cancer |
| Amy Forward | The use of thermal desorption techniques to establish a suitable quantitative method of analysing drugs on money |
| Bethany Fox | The development of fluorescence sensing for monitoring microbial processes in freshwater systems |
| Mark Fraser | Novel approaches to the detection of antifungal resistance in candida spp’ |
| Oliver Gould | The detection of trace volatiles as potential biomarkers of disease using gas chromatography mass spectrometry (GCMS) techniques and selected ion flow tube mass spectrometry (SIFT-MS) assessment of volatiles produced from nitric oxide producing smart dressings |
| Keith Hewett | In vitro modelling of tongue microbial biofilms and their response to treatments |
| Fred Hudd | Regulation of neurotransmitter synthesis in Alzheimer’s disease – potential for dietary supplements to improve cognition |
| Samantha Jumbe | ‘Targeting the splice factor kinases SRPK1 and CLK1 in prostate cancer |
| Saeed Kabrah | Development of a three-dimensional physiologically relevant model of the bone marrow; comparison of in-vitro functionality with bone marrow from in-vivo chemotherapy treated lymphoma and leukaemia patients |
| Marian Manso | Fluid reabsorption across bladder urothelium |
| Bertrand Monnier | ‘Development of a rapid and cost effective ‘on-site’ detection method for Cacao Swollen Shoot Virus (CSSV) |
| Janet Mundy | Individual differences in spatial abilities and task strategy |
| Kelechi Okeke | Exploration of a chemotherapy induced bystander effect in the aetiology of therapy related or donor cell leukaemia |
| Grace Okoro | The impact of alcohol and toxic metabolites on neurotransmitter synthesis and protein misfolding in neurodegenerative conditions |
| Joseph Payne | Quantum pathogen evolution by integron-mediated effector capture |
| Josie Phillips | Does the relationship between biodiversity and ecosystem function change during conversion of tropical forest to oil palm plantation? |
| Mai Shafei | Biomarkers and therapeutic targets for solid tumours |
| Elisabeth Slade | Biofilms in wounds; using microbial metabolomics for the rapid diagnosis of wound infection |
| Richard Thompson | Investigating the efficacy of bacteriophage therapy for preventing the encrustation and blockage of urinary catheters |
| Wilasinee Triyarat | Developing a regional framework for science communication activities in Thailand |
| Andrew Turner | Development and application of gene scanning techniques for the diagnosis of a thalassaemia trait or traits |
| Simon Uzor | Analogy of the prostate specific antigen of smokers |
| Kelly Westmacott | Novel technology (bio-sensors) for boar taint detection to assist with projection of taint-free pork |
| Chigeru Wodi | An investigation into the function of the splice factor kinase SRPK1 |
Professional doctorates
| Khaled Abuzariba | Vitamin D status in type 2 diabetic patients with various degrees of glycaemic control |
| Sephora Aquilina | Development of in vitro long term cultures of erythroblasts for transfusion purposes |
| Emmanuel Azore | Molecular characterisation and virulence determinants of research models associated Staphylococcus aureus (RMA-SA) |
| Elanne Christie | Identifying and measuring key constraints impacting on the five Clinical Compliance Officers in the Scottish National Blood Transfusion Service in achieving regulatory compliance with the Blood Safety and Quality Regulations (BSQR) through the theoretical lens of Activity Theory |
| Paradzai Chitongo | A prospective case-control study to investigate the prothrombotic phenotype of severely obese patients |
| Susan Davey | A novel genotyping approach to improve transfusion support for patients with HLA and/or HPA alloantibodies |
| Jeni Davies | Developing a strategy for red cell antigen typing and matching of blood for transfusion in chronically transfused patients |
| James Dowds | Mechanisms of tumour progression from Ductal Carcinoma in-situ (DCIS) to invasive carcinoma |
| Wendy Etheridge | Development of a novel automated assay for the detection of antibodies to red cell antigens |
| Ivo Fombon | Role of cystatin C in the evaluation of renal function in patients receiving fenofibrate treatment for dyslipidaemia |
| Matthew Griffiths | Data monitoring if key performance indicators can be used to ensure quality of histological dissection performed by biomedical scientists |
| Noel Jereza | 'The incidence of coexistent Hepcidin (HAMP)/HFE Haemochromatosis Gene Mutations and iron overload in Irish patients with Dilated Cardiomyopathy (DCM) |
| Zacharias Kallis | Investigation of the quality of cord blood units and the isolation of progenitor cells from umbilical cord tissue processed and cryopreserved as cellular therapy products by an international family cord blood bank |
| Jonathan Lewis | The incidence and molecular characteristics of clinical Escherichia coli Isolates producing AmpC Beta-lactamase enzymes' |
| Linda Matthews | Exploring the implications of changing patterns of Rubella immunity in antenatal women in South Wales Valley Community |
| Sherina Murden | The use of next generation DNA sequencing for the molecular diagnosis and characterisation of Hermansky Pudlak Syndrome |
| Nigel Oakes | The expression of Toll like receptors on T and B Lymphocytes in Chronic Lymphocyctic Leukaemia; links with prognosis and association with autoimmune disease |
| Samantha Osmond | 'Quantification of cannabinoids by novel HPLC methods to distinguish frequency from duration since last use |
| Anthony Poles | Glycoprotein estimation and analysis of genes associated with inherited platelet disorders and complications of pregnancy |
| Janet Wells | A study of regulatory T cells and clinical outcome in patients undergoing haematological transplantation |
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