Dysfunctional neurogenesis in Alzheimer’s Disease: A link between diet and neurodegeneration?

Introduction

An exciting opportunity to apply for a funded full-time PhD in the Faculty of Health and Applied Sciences, UWE Bristol. The studentship will be internally funded. Reference: 2022-JAN-HAS01.

The expected start date of this studentship is 1 January 2022.

The closing date for applications is Sunday 5 September 2021.

About the studentship

Alzheimer’s Disease (AD) is the most common cause of dementia, with an estimated 30 million sufferers worldwide. Despite many recent advances, much is still not understood about the disease, especially the most common form, Late Onset Alzheimer's Disease (LOAD). Type-2 Diabetes Mellitus (T2DM) is one of the most significant risk factors for developing LOAD, although the link between these two diseases is poorly understood. One possibility is that metabolic dysfunction in T2DM disrupts de novo neurogenesis in areas of the brain such as the hippocampus, leading to the early events of LOAD. Indeed, recent studies have demonstrated defective neurogenesis and neuronal metabolic disruption in LOAD, supporting this hypothesis.

This innovative project will investigate this hypothesis using the cutting edge metabolic, imaging and cell biology facilities in the Centre for Research in Biosciences at UWE Bristol. You will join a thriving Research Centre, which has extensive expertise in all the techniques for this project, and you will be provided with expert training in all the methods required. You will also benefit from the extensive support networks, training opportunities and careers guidance provided to graduate students at the University.

For an informal discussion about the studentship, please email Dr Tim Craig (Tim.Craig@uwe.ac.uk).

Funding

The studentship is available from 1 January 2022 for a period of three years, subject to satisfactory progress and includes a tax exempt stipend, which is currently £15,609 per annum.

In addition, full-time tuition fees will be covered for up to three years (Home/EU rates only). Overseas applicants will be required to cover the difference between Home/EU and the overseas tuition fee rates in each year of study.

Eligibility

Applicants must have at least a 2:1 or equivalent undergraduate qualification in a relevant Biological Sciences subject, ideally with knowledge of cellular and molecular neuroscience.

A recognised English language qualification is required.

How to apply

Please submit your application online. When prompted, use the reference number 2022-JAN-HAS01Applications which do not include a studentship reference number cannot be considered for shortlisting.

Supporting documentation: you will need to upload your research proposal, all your degree certificates and transcripts and your proof of English language proficiency as attachments to your application, so please have these available when you complete the application form. Applications which are incomplete at the application deadline will not be considered for shortlisting.

References: you will need to provide details of two referees as part of your application. At least one referee must be an academic referee from the institution that conferred your highest degree. Your referee will be asked for a reference at the time you submit your application, so please ensure that your nominated referees are willing and able to provide references within 14 days of your application being submitted. 

Closing date

The closing date for applications is Sunday 5 September 2021.

Further information

Interviews will take place on Friday 29 October 2021.  If you have not heard from us by that date, we thank you for your application but, on this occasion, you have not been successful